A prudent path forward for genomic engineering and germline gene modification
نویسندگان
چکیده
منابع مشابه
Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed Correspondence to: Jennifer A. Doudna, [email protected]. HHS Public Access Author manuscript Science. Author manuscript; available in PMC 2015 October 03. Published in final edited form as: Science. 2015 April 3; 348(6230): 36–38. doi:10.1126/science.aab1028. A uhor M anscript
متن کاملGermline Modification and Engineering in Avian Species
Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, t...
متن کاملBackward and forward path following control of a wheeled robot
A wheeled mobile robot is one of the most important types of mobile robots. A subcategory of these robots is wheeled robots towing trailer(s). Motion control problem, especially in backward motion is one of the challenging research topics in this field. In this article, a control algorithm for path-following problem of a tractor-trailer system is provided, which at the same time provides the ab...
متن کاملGenomic signatures of germline gene expression.
Transcribed regions in the human genome differ from adjacent intergenic regions in transposable element density, crossover rates, and asymmetric substitution and sequence composition patterns. We tested whether these differences reflect selection or are instead a byproduct of germline transcription, using publicly available gene expression data from a variety of germline and somatic tissues. Cr...
متن کاملPrudent engineering practice for cryptographic protocols
We present principles for the design of cryptographic protocols. The principles are neither necessary nor sufficient for correctness. They are however helpful, in that adherence to them would have avoided a considerable number of published errors. Our principles are informal guidelines. They complement formal methods, but do not assume them. In order to demonstrate the actual applicability of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2015
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aab1028